Title :
New blockwise permutation tests preserving exchangeability in functional neuroimaging
Author :
Zhou, Chunxiao ; Wang, Yongmei Michelle
Author_Institution :
Electr. & Comput. Eng. Dept., Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA
Abstract :
In this paper, we present a new blockwise permutation test approach based on the moments of the test statistic. The method is of importance to functional neuroimaging studies. In order to preserve the exchangeability condition required in permutation, we divide the time series into certain exchangeability blocks. In addition, efficient moments-based permutation tests are performed by approximating the permutation distribution of the test statistic with the Pearson distribution series. This involves the calculation of the first four moments of the permutation distribution within each block and then over the whole time series. The accuracy and efficiency of the proposed method are demonstrated using both simulated time series and fMRI data.
Keywords :
biomedical MRI; method of moments; neurophysiology; statistical testing; time series; Pearson distribution series; blockwise permutation test; exchangeability; functional MRI data; functional neuroimaging; magnetic resonance imaging; moments-based permutation test; time series; Acoustic Stimulation; Auditory Cortex; Biomedical Engineering; Biostatistics; Brain; Humans; Magnetic Resonance Imaging;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333853