Title :
Molding single DNA molecules in metals and sample preparation for electronic sequencing
Author :
Lund, John A. ; Parviz, Babak A.
Author_Institution :
Electr. Eng. Dept., Univ. of Washington, Seattle, WA, USA
Abstract :
We demonstrate the molding of single DNA molecules in 8 nm thin platinum molds. The molded structures have an apparent depth of 1 nm under STM imaging, and closely follow the contours of the DNA molecules. We have confirmed the presence of the embedded molecules and have verified the ability of this technique to scale down to single molecules. Additionally, we have utilized this method to perform electron tunneling analysis on embedded DNA molecules.
Keywords :
DNA; biological techniques; molecular biophysics; moulding; platinum; scanning tunnelling microscopy; DNA molecule; DNA sequencing; Pt; STM imaging; depth 1 nm; electron tunneling analysis; electronic sequencing; molded structures; size 8 nm; thin platinum molds; Bacteriophage lambda; Carbon; DNA; Electric Conductivity; Electrochemistry; Electronics; Electrons; Metals; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Scanning Tunneling; Platinum; Reproducibility of Results;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333862