Title :
Identification of markers of cardiovascular disease in women and the reconstruction of its corresponding protein interaction network
Author :
Camargo, A. ; Kim, J.T.
Author_Institution :
Sch. of Comput., Univ. of East Anglia, Norwich, UK
Abstract :
Cardiovascular disease is the second most prevalent cause of morbidity and mortality in women of developed countries. Although it is well established that gender is a risk factor for cardiovascular disease, most gene expression analysis studies favour the identification of disease bio-markers and potential drug targets over combined populations. This study integrates genomic and systems approaches to identify a female-related set of genes that intervene in signal and metabolic pathways leading to cardiovascular disease.
Keywords :
cardiovascular system; diseases; drugs; genetics; genomics; molecular biophysics; proteins; cardiovascular disease marker identification; drug targets; gene expression analysis; genomic approach; metabolic pathways; protein interaction network; risk factor; Biological Markers; Biomedical Engineering; Cardiovascular Diseases; Female; Gene Expression Profiling; Genetic Markers; Humans; Metabolic Networks and Pathways; Protein Interaction Mapping; Systems Biology;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5333879