Patch-basis electrocortical source imaging in epilepsy

In this study, we developed numerical methods for investigating the sources of epileptic activity from intracranial EEG recordings acquired from intracranial subdural electrodes (iEEG) in patients undergoing pre-surgical evaluation at the epilepsy center of the Mayo Clinic (Rochester, MN). The data were analyzed using independent component analysis (ICA), which identifies and isolates maximally independent signal components in multi-channel recordings. A realistic individual head model was constructed for a patient undergoing pre-surgical evaluation. Structural models of gray matter, white matter, CSF, skull, and scalp were extracted from pre-surgical MR and post-surgical CT images. The electromagnetic source localization forward problem was solved using the Boundary Element Method (BEM). Source localization was performed using the Sparse Bayesian Learning (SBL) algorithm. The multiscale patch-basis source space constructed for this purpose includes a large number of dipole elements on the cortical layer oriented perpendicular to the local cortical surface. These source dipoles are combined into overlapping multi-scalepatches. Using this approach, we were able to detect seizure activity on sulcal walls and on gyrus of the cortex.