Integrated electronics for peripheral nerve recording and signal processing

This paper describes the integrated circuit implementation of an electronic system for peripheral nerve recording and signal processing. Specifically, the system aims to record and condition neural activity from the phrenic nerve as a good indicator for breathing, and generate a stimulus trigger signal for a laryngeal pacemaker device to reanimate a paralyzed muscle with electrical stimulation paced with respiration. The 2.2 times 2.2-mm² integrated circuit is fabricated using the AMI 1.5 mum 2P/2M n-well CMOS process, and consumes 1 mW from plusmn1.5 V. System architecture, circuit design, simulation results, and measurement data in benchtop experiments are presented.