DocumentCode :
2410953
Title :
Development of a multispectral tissue characterization system for optimization of an implantable perfusion status monitor for transplanted liver
Author :
Baba, J.S. ; Letzen, B.S. ; Ericson, M.N. ; Coté, G.L. ; Xu, W. ; Wilson, M.A.
Author_Institution :
Meas. Sci.&Syst. Eng. Div., Oak Ridge Nat. Lab., Oak Ridge, TN, USA
fYear :
2009
fDate :
3-6 Sept. 2009
Firstpage :
6565
Lastpage :
6568
Abstract :
Optimizing wavelength selection for monitoring perfusion during liver transplant requires an in-depth characterization of liver optical properties. With these, the impact of liver absorption and scattering properties can be investigated to select optimal wavelengths for perfusion monitoring. To accomplish this, we are developing a single integrating-sphere-based technique using a unique spatially resolved diffuse reflectance system for multispectral optical properties determination for thick samples. We report early results using a monochromatic source to measure the optical properties of well characterized tissue phantoms made from polystyrene spheres and Trypan blue. The presented results demonstrate the feasibility of using this unique system to measure optical properties of tissue phantoms. We are currently in the process of implementing an automated Levenberg-Marquardt diffuse-reflectance-profile fitting algorithm to enable near realtime robust computation of sample optical properties. Future work will focus on the incorporation of multispectral capability to provide needed data to facilitate development of more realistic liver tissue phantoms.
Keywords :
bio-optics; biological tissues; biology computing; biomedical optical imaging; liver; optimisation; phantoms; prosthetics; Trypan blue; automated Levenberg-Marquardt diffuse-reflectance-profile fitting algorithm; implantable perfusion status monitor; integrating-sphere-based technique; liver absorption property; liver scattering property; liver tissue phantoms; monochromatic source; multispectral capability; multispectral optical property; multispectral tissue characterization system; optimization; polystyrene spheres; resolved diffuse reflectance system; transplanted liver; Animals; Diffusion; Hemoglobins; Liver; Liver Transplantation; Mice; Optical Phenomena; Oxygen; Perfusion; Prostheses and Implants; Tomography, X-Ray Computed;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
ISSN :
1557-170X
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2009.5334499
Filename :
5334499
Link To Document :
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