Title :
A personalized and optimal approach for dosing contrast material at coronary computed tomography angiography
Author :
Kalafut, John F. ; Kemper, Corey A. ; Suryani, Pal ; Schoepf, U. Joseph
Author_Institution :
MEDRAD Inc., Indianola, PA, USA
Abstract :
A method for constructing a personalized contrast medium protocol at contrast enhanced, Coronary CT Angiography (CCTA) is presented. A one compartment pharmacokinetic model is parameterized and identified with a minimal data set from a test-bolus injection. A direct-search optimization is performed to construct a protocol that achieves target enhancement in the cardiac structures. Clinical results demonstrating the method´s ability to achieve prospectively chosen image enhancement levels while reducing contrast medium dose are presented.
Keywords :
angiocardiography; computerised tomography; image enhancement; medical image processing; cardiac structures; coronary computed tomography angiography; direct-search optimization; image enhancement; one compartment pharmacokinetic model; personalized contrast medium protocol; test-bolus injection; Algorithms; Angiography; Aorta; Contrast Media; Coronary Angiography; Heart; Humans; Image Processing, Computer-Assisted; Iodine; Models, Statistical; Pharmacokinetics; Radiographic Image Interpretation, Computer-Assisted; Technology, Pharmaceutical; Time Factors; Tomography, X-Ray Computed;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5334533