A personalized and optimal approach for dosing contrast material at coronary computed tomography angiography

Author

Kalafut, John F. ; Kemper, Corey A. ; Suryani, Pal ; Schoepf, U. Joseph

Author_Institution

MEDRAD Inc., Indianola, PA, USA

fYear

2009

fDate

3-6 Sept. 2009

Firstpage

3521

Lastpage

3524

Abstract

A method for constructing a personalized contrast medium protocol at contrast enhanced, Coronary CT Angiography (CCTA) is presented. A one compartment pharmacokinetic model is parameterized and identified with a minimal data set from a test-bolus injection. A direct-search optimization is performed to construct a protocol that achieves target enhancement in the cardiac structures. Clinical results demonstrating the method´s ability to achieve prospectively chosen image enhancement levels while reducing contrast medium dose are presented.

Keywords

angiocardiography; computerised tomography; image enhancement; medical image processing; cardiac structures; coronary computed tomography angiography; direct-search optimization; image enhancement; one compartment pharmacokinetic model; personalized contrast medium protocol; test-bolus injection; Algorithms; Angiography; Aorta; Contrast Media; Coronary Angiography; Heart; Humans; Image Processing, Computer-Assisted; Iodine; Models, Statistical; Pharmacokinetics; Radiographic Image Interpretation, Computer-Assisted; Technology, Pharmaceutical; Time Factors; Tomography, X-Ray Computed;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Conference_Location

Minneapolis, MN

ISSN

1557-170X

Print_ISBN

978-1-4244-3296-7

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2009.5334533

Filename

5334533