DocumentCode :
2412863
Title :
MiRNAs as promising phylogenetic markers for inferring deep metazoan phylogeny and in support of Olfactores hypothesis
Author :
Cai, Qingqing ; Zhang, Xiaoyan ; Li, Zoufeng
Author_Institution :
Sch. of Life Sci. & Technol., Tongji Univ., Shanghai, China
fYear :
2010
fDate :
18-21 Dec. 2010
Firstpage :
101
Lastpage :
104
Abstract :
The Long Branch attraction (LBA) artefact induced by fast evolving Urochordata had hindered the interpretation of relationships among 3 subphyla of Chordata. Although Olfactores hypothesis which placed Urochordata rather than Cephalochordata as the closest relatives to Craniata was gradually accepted, every step of phylogenetic reconstruction had to be treated prudential to minimize LBA phenomenon. MiRNAs (microRNAs) are well known for their 1) adherence to organism development, 2) high conservation, and 3) rarity of secondary loss, parallel evolution, and convergence among metazoan. Therefore we suppose miRNAs to be promising candidates to dispel LBA phenomenon. We performed a phylogenetic study upon 35 pre-miRNA datasets and reconstruct Chordata phylogeny which supported Olfactores hypothesis in a more toilless way by applying fewer datasets and unspecified substitution model. This is the first attempt to apply miRNA sequences in interpreting Chordata phylogeny, and we reckon miRNAs as promising phylogenetic markers for illuminating deuterostome evolution.
Keywords :
bioinformatics; evolution (biological); genetics; molecular biophysics; zoology; Cephalochordata; Craniata; LBA phenomenon; Olfactores hypothesis; Urochordata; deep metazoan phylogeny; deuterostome evolution; long branch attraction artefact; miRNA sequences; microRNA; phylogenetic markers; phylogenetic reconstruction; Bayesian methods; Bioinformatics; Genomics; Humans; Phylogeny; Topology; Olfactores hypothesis; microRNA; phylogeny;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-8306-8
Electronic_ISBN :
978-1-4244-8307-5
Type :
conf
DOI :
10.1109/BIBM.2010.5706545
Filename :
5706545
Link To Document :
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