Title :
Automated biomanipulation of single cells
Author :
Steager, Edward B. ; Sakar, Mahmut Selman ; Magee, Ceridwen ; Kennedy, Monroe ; Cowley, Anthony ; Kumar, Vijay
Author_Institution :
GRASP Lab., Univ. of Pennsylvania, Philadelphia, PA, USA
Abstract :
Transport of individual cells or chemical payloads on a subcellular scale is an enabling tool for the study of cellular communication, cell migration, and other localized phenomena. We present a magnetically actuated robotic system for the fully automated manipulation of cells and microbeads. Our strategy uses autofluorescent robotic transporters and fluorescently labeled microbeads to aid tracking and control in optically obstructed environments. We demonstrate automated delivery of microbeads infused with chemicals to specified positions on neurons.
Keywords :
biology; cellular transport; manipulators; autofluorescent robotic transporters; automated biomanipulation; automated delivery; biological sciences; cell migration; cell transport; cellular communication; chemical payloads; fluorescent labeled microbeads; localized phenomena; magnetical actuated robotic system; neurons; optical obstructed environments; single cells; subcellular scale; Biomedical optical imaging; Fluorescence; Integrated optics; Nanobioscience; Optical imaging; Standards;
Conference_Titel :
Robotics and Automation (ICRA), 2012 IEEE International Conference on
Conference_Location :
Saint Paul, MN
Print_ISBN :
978-1-4673-1403-9
Electronic_ISBN :
1050-4729
DOI :
10.1109/ICRA.2012.6224945
