DocumentCode
2413269
Title
Iterative correction of suppressed peptide profiles from FTMS measurements
Author
Ma, Xuepo ; Travis, J. Hestilow ; Cui, Jian ; Zhang, Jianqiu
Author_Institution
Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, TX, USA
fYear
2010
fDate
18-21 Dec. 2010
Firstpage
222
Lastpage
227
Abstract
Analysis of peptide profiles from a Liquid Chromatography Fourier Transform Mass Spectrometry (LC/FTMS) measurement reveals a non-linear distortion in intensity. Investigation of the measured CVi /C12 ratios comparing with theoretical ones shows that the non-linearity can be attributed to low intensity signal suppression of low abundance peptide peaks. We find that the suppression is homogenous for different isotopes of identical peptides but non-homogenous for different peptides. We developed an iterative correction algorithm that corrects the intensity distortions for peptides with relatively high abundance. This algorithm can be applied in a wide range of applications using FTMS.
Keywords
ICM; LC/FTMS; correction; suppression;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on
Conference_Location
Hong Kong
Print_ISBN
978-1-4244-8306-8
Type
conf
DOI
10.1109/BIBM.2010.5706567
Filename
5706567
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