Title :
Sparse nonnegative matrix factorization with the elastic net
Author :
Liu, Weixiang ; Zheng, Songfeng ; Jia, Sen ; Shen, Linlin ; Fu, Xianghua
Author_Institution :
Dept. of Biomed. Eng., Shenzhen Univ., Shenzhen, China
Abstract :
Nonnegative matrix factorization is used extensively for feature extraction and clustering analysis. Recently many sparsity/sparseness constraints, such as L1 penalty, are introduced for sparse nonnegative matrix factorization. Inspired by sparsity measures from linear regression model, this paper proposes to integrate nonnegative matrix factorization with another sparsity constraint, the elastic net. The experimental results of clustering analysis on three gene expression datasets demonstrate the effectiveness of the proposed method.
Keywords :
bioinformatics; feature extraction; genetics; pattern clustering; regression analysis; sparse matrices; clustering analysis; elastic net; feature extraction; gene expression; linear regression model; sparse nonnegative matrix factorization; Accuracy; Bioinformatics; Cancer; Data analysis; Encoding; Gene expression; Sparse matrices; Nonnegative matrix factorization; clustering analysis; gene expression data; sparsity penalty;
Conference_Titel :
Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-8306-8
Electronic_ISBN :
978-1-4244-8307-5
DOI :
10.1109/BIBM.2010.5706574