Title :
Target controlled infusion algorithms for anesthesia: Theory vs practical implementation
Author :
Bressan, Nadja ; Moreira, A. Paulo ; Amorim, Pedro ; Nunes, Catarina S.
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Porto, Porto, Portugal
Abstract :
Target Controlled Infusion (TCI) systems are based in drug pharmacokinetic and pharmacodynamic models implemented in an algorithm to drive an infusion pump. Infusion control algorithms have been designed, implemented and validated for several anesthetic drugs, devices and controllers. The maintenance phase in these algorithms is represented by an equation that compensates the loss of drug from the central compartment and maintains the set target concentration. The goal of the current study was to improve existing TCI software with a new method for the maintenance phase. We compared and analyzed two different methods to find the more efficient method for the maintenance phase in an open-loop control TCI system.
Keywords :
control system synthesis; drug delivery systems; drugs; medical computing; medical control systems; open loop systems; pumps; anesthesia; computer-assisted infusion device; drug pharmacokinetic model; infusion pump; open-loop control TCI system; pharmacodynamic model; target controlled infusion algorithm; Algorithms; Anesthetics, General; Computer Simulation; Drug Therapy, Computer-Assisted; Humans; Infusions, Intravenous; Models, Biological; Reproducibility of Results; Sensitivity and Specificity;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5334653
