• DocumentCode
    2416568
  • Title

    A CMOS Image Sensor for DNA Microarrays

  • Author

    Parikh, Samir ; Gulak, Glenn ; Chow, Paul

  • Author_Institution
    Univ. of Toronto, Toronto
  • fYear
    2007
  • fDate
    16-19 Sept. 2007
  • Firstpage
    821
  • Lastpage
    824
  • Abstract
    An image sensor designed with standard 0.18 mum CMOS technology is used to construct a DNA microarray scanner. The detection limit of 4590 fluorophores/mum2 is compared with 4.49 fluorophores/mum2 of a commercial photomultiplier-tube-based microarray scanner. The performance gap can be reduced by improving optical coupling, mechanical alignment, laser power supply noise, improved circuit noise and an increase in the conversion gain. The CMOS sensor offers multiple-pixels for reduced scan time and an integrated analog-to-digital converter.
  • Keywords
    CMOS image sensors; DNA; biosensors; CMOS image sensor; DNA microarray scanner; analog-to-digital converter; laser power supply noise; mechanical alignment; optical coupling; photomultiplier tube based microarray scanner; size 0.18 mum; CMOS image sensors; CMOS technology; DNA; Image sensors; Laser noise; Noise reduction; Optical coupling; Optical noise; Power lasers; Power supplies;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Custom Integrated Circuits Conference, 2007. CICC '07. IEEE
  • Conference_Location
    San Jose, CA
  • Print_ISBN
    978-1-4244-1623-3
  • Electronic_ISBN
    978-1-4244-1623-3
  • Type

    conf

  • DOI
    10.1109/CICC.2007.4405854
  • Filename
    4405854
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2416568