Title :
A CMOS Image Sensor for DNA Microarrays
Author :
Parikh, Samir ; Gulak, Glenn ; Chow, Paul
Author_Institution :
Univ. of Toronto, Toronto
Abstract :
An image sensor designed with standard 0.18 mum CMOS technology is used to construct a DNA microarray scanner. The detection limit of 4590 fluorophores/mum2 is compared with 4.49 fluorophores/mum2 of a commercial photomultiplier-tube-based microarray scanner. The performance gap can be reduced by improving optical coupling, mechanical alignment, laser power supply noise, improved circuit noise and an increase in the conversion gain. The CMOS sensor offers multiple-pixels for reduced scan time and an integrated analog-to-digital converter.
Keywords :
CMOS image sensors; DNA; biosensors; CMOS image sensor; DNA microarray scanner; analog-to-digital converter; laser power supply noise; mechanical alignment; optical coupling; photomultiplier tube based microarray scanner; size 0.18 mum; CMOS image sensors; CMOS technology; DNA; Image sensors; Laser noise; Noise reduction; Optical coupling; Optical noise; Power lasers; Power supplies;
Conference_Titel :
Custom Integrated Circuits Conference, 2007. CICC '07. IEEE
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-4244-1623-3
Electronic_ISBN :
978-1-4244-1623-3
DOI :
10.1109/CICC.2007.4405854
