Title :
A CMOS Array Sensor for Sub-800-ps Time-Resolved Fluorescence Detection
Author :
Huang, T. ; Sorgenfrei, S. ; Shepard, K.L. ; Gong, P. ; Levicky, R.
Author_Institution :
Columbia Univ., New York
Abstract :
This paper describes the design of an active CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64 times 64 array is sensitive to photon densities as low as 8 times 106 photons/cm with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.
Keywords :
CMOS image sensors; fluorescence spectroscopy; sensor arrays; CMOS array sensor; active CMOS sensor array; differential pixel design; fluorescence applications; fluorescence detection; fluorescence lifetime imaging microscopy; fluorescence spectroscopy; high-frame-rate imagers; impulse response; photon density; Biosensors; Chemical and biological sensors; Chemical engineering; Decoding; Detectors; Fluorescence; Microscopy; Optical filters; Optoelectronic and photonic sensors; Sensor arrays;
Conference_Titel :
Custom Integrated Circuits Conference, 2007. CICC '07. IEEE
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-4244-1623-3
Electronic_ISBN :
978-1-4244-1623-3
DOI :
10.1109/CICC.2007.4405856
