Title :
Engineering NIR dyes for fluorescent lifetime contrast
Author :
Berezin, Mikhail Y. ; Lee, Hyeran ; Akers, Walter ; Guo, Kevin ; Goiffon, Reece J. ; Almutairi, Adah ; Fréchet, Jean M J ; Achilefu, Samuel
Author_Institution :
Sch. of Med., Dept. of Radiol., Washington Univ., St. Louis, MO, USA
Abstract :
The excited state of an organic molecule is a crossroads which can lead to many directions, such as non-radiative emission as heat, fluorescence, intersystem crossing and phosphorescence. Due to the unpredictable nature of the excited molecular structure, manipulation of this represents significant challenges for physicists and chemists. However, the successful management of the excited state provides a number of benefits with innumerable applications to fields like photonics and medicine. One such property of the excited state with powerful ramifications in medical diagnostics is fluorescence lifetime.
Keywords :
biodegradable materials; biomedical optical imaging; dyes; excited states; fluorescence; radiative lifetimes; NIR dyes; biodegradable dendrimer; fluorescence lifetime imaging; fluorescent lifetime contrast; medical diagnostics; molecular structure; organic molecule excited state; Animals; Contrast Media; Drug Design; Fluorescent Dyes; Image Enhancement; Kinetics; Mice; Microscopy, Fluorescence; Spectroscopy, Near-Infrared; Time Factors; Whole Body Imaging;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5334834
