DocumentCode :
2420303
Title :
Scaling exponents of EEG are related to the temporal process of the therapeutic hypothermia following ischemic brain injury
Author :
Jiang, Dineng ; Wu, Wenqing ; Jia, Xiaofeng ; Qiu, Yihong ; Zhu, Yisheng ; Thakor, Nitish ; Tong, Shanbao
Author_Institution :
Dept. of Biomed. Eng., Shanghai Jiao Tong Univ., Shanghai, China
fYear :
2009
fDate :
3-6 Sept. 2009
Firstpage :
2192
Lastpage :
2195
Abstract :
Several markers based on quantitative electroencephalogram (qEEG) analysis have been associated with the neuroprotective effects of therapeutic hypothermia on hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). Nevertheless, the makers by far have not been linked to the temporal process of the ischemic neuronal death. In this study, we investigated the long-range correlations in EEG power in thetas and alpha bands before and after CA by detrended fluctuation analysis (DFA). The scaling components by DFA showed that the short-term scaling exponent in alpha band (i.e. gamma1 alpha) was well correlated with recovery of brain injury during the latent phase. While the short-term scaling exponent in thetas band (i.e. gamma1 thetas) and the long-term scaling exponent in alpha band (i.e. gamma2 alpha) were correlated with the delayed neuronal death after CA. Our preliminary results showed that the long-range correlations in thetas and alpha bands could be related the detail temporal process of therapeutic hypothermia.
Keywords :
biothermics; brain; cardiology; correlation methods; diseases; electroencephalography; neurophysiology; patient treatment; wounds; EEG scaling exponents; cardiac arrest; detrended fluctuation analysis; hypoxic-ischemic encephalopathy; ischemic brain injury; ischemic neuronal death; neuroprotective effects; quantitative electroencephalogram analysis; temporal process; therapeutic hypothermia; Animals; Anoxia; Biomedical Engineering; Brain Injuries; Brain Ischemia; Brain Mapping; Electroencephalography; Heart Arrest; Hypothermia, Induced; Male; Neurons; Rats; Rats, Wistar; Software; Time Factors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
ISSN :
1557-170X
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2009.5334934
Filename :
5334934
Link To Document :
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