Title :
Controlled formulation of doxorubicin-polylactide nanoconjugates for cancer drug delivery
Author :
Tong, Rong ; Tang, Li ; Yala, Linda ; Cheng, Jianjun
Author_Institution :
Nat. Inst. of Stand. & Technol., Boulder, CO, USA
Abstract :
We report here the synthesis of doxorubicin-polylactide conjugate via doxorubicin-initiated lactide polymerization.
Keywords :
biomedical materials; cancer; drug delivery systems; nanobiotechnology; polymerisation; polymers; cancer drug delivery; doxorubicin-initiated lactide polymerisation; doxorubicin-polylactide nanoconjugate synthesis; Antineoplastic Agents; Chemistry, Pharmaceutical; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Design; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Nanoparticles; Neoplasms; Polyesters; Polymers; Spectroscopy, Fourier Transform Infrared;
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2009.5334938
