DocumentCode :
2422133
Title :
Simulation of erythrocyte deformation in a high shear flow
Author :
Nakamura, Masanori ; Bessho, Sadao ; Wada, Shigeo
Author_Institution :
Center for Adv. Med. Eng. & Inf., Osaka Univ., Osaka, Japan
fYear :
2009
fDate :
3-6 Sept. 2009
Firstpage :
2358
Lastpage :
2361
Abstract :
Deformation of a red blood cell (RBC) in a high-shear flow was investigated. The RBC was modeled as a closed shell membrane consisting of spring networks in the framework of the energy minimum concept. The simulation of RBC in a parallel shear flow showed deformation parameters of RBC were well agreed with experimental results. The simulation of RBC behavior in various flow fields demonstrated that the shape was determined not only by instantaneous fluid force acting on it but also its deformation history. No consistency was found between the maximum of the first principal strain and conventionally used hemolysis index. Those results addressed the importance of considering an RBC deformation for accurately predicting hemolysis.
Keywords :
biomechanics; blood; cellular biophysics; deformation; haemodynamics; shear flow; RBC deformation history; RBC deformation parameters; closed shell membrane model; energy minimum concept; erythrocyte deformation simulation; first principal strain maximum; hemolysis index; hemolysis prediction; high shear flow; instantaneous fluid force; parallel shear flow; red blood cell deformation; spring networks; Algorithms; Biomedical Engineering; Computer Simulation; Erythrocyte Deformability; Erythrocyte Membrane; Erythrocytes; Hemodynamics; Hemolysis; Humans; Models, Cardiovascular; Models, Statistical; Models, Theoretical; Shear Strength; Stress, Mechanical;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE
Conference_Location :
Minneapolis, MN
ISSN :
1557-170X
Print_ISBN :
978-1-4244-3296-7
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2009.5335025
Filename :
5335025
Link To Document :
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