Nanoparticle-Amplified Optical Interferometer Biosensor toward Single Molecular Detection

Author

Shew, B.Y. ; Wei, S.L. ; Tsail, Y.H. ; Cheng, Y.C. ; Fu, C.C.

Author_Institution

Device Technol. Group, National Synchrotron Radiat. Res. Center, Hsinchu

fYear

2007

fDate

16-19 Jan. 2007

Firstpage

127

Lastpage

130

Abstract

This paper reports a new method using a NIR Mach-Zehnder interferometer (MZI), plus conjugated gold nanoparticle, to achieve ultra-sensitive biochemical detection. Due to the combination of interferometric measurement, long interaction length and nanoparticle amplification, the MZI chip can detect the analyte with a equipollent concentrations of 105 molecular/ml or 10-14 g/ml, which is approaching the ultimate goal of single molecular detection.

Keywords

Mach-Zehnder interferometers; amplification; biosensors; gold; nanoparticles; optical waveguides; NIR Mach-Zehnder interferometer; conjugated gold nanoparticle; long interaction length; nanoparticle amplification; optical interferometer biosensor; single molecular detection; ultra-sensitive biochemical detection; Biomedical optical imaging; Biosensors; Nanobioscience; Optical interferometry; Optical refraction; Optical resonators; Optical sensors; Optical surface waves; Optical variables control; Optical waveguides; biosensor; nanoparticle; planar interferometer; sensitivity;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems, 2007. NEMS '07. 2nd IEEE International Conference on

Conference_Location

Bangkok

Print_ISBN

1-4244-0610-2

Type

conf

DOI

10.1109/NEMS.2007.352245

Filename

4160548