Title :
Nanoparticle-Amplified Optical Interferometer Biosensor toward Single Molecular Detection
Author :
Shew, B.Y. ; Wei, S.L. ; Tsail, Y.H. ; Cheng, Y.C. ; Fu, C.C.
Author_Institution :
Device Technol. Group, National Synchrotron Radiat. Res. Center, Hsinchu
Abstract :
This paper reports a new method using a NIR Mach-Zehnder interferometer (MZI), plus conjugated gold nanoparticle, to achieve ultra-sensitive biochemical detection. Due to the combination of interferometric measurement, long interaction length and nanoparticle amplification, the MZI chip can detect the analyte with a equipollent concentrations of 105 molecular/ml or 10-14 g/ml, which is approaching the ultimate goal of single molecular detection.
Keywords :
Mach-Zehnder interferometers; amplification; biosensors; gold; nanoparticles; optical waveguides; NIR Mach-Zehnder interferometer; conjugated gold nanoparticle; long interaction length; nanoparticle amplification; optical interferometer biosensor; single molecular detection; ultra-sensitive biochemical detection; Biomedical optical imaging; Biosensors; Nanobioscience; Optical interferometry; Optical refraction; Optical resonators; Optical sensors; Optical surface waves; Optical variables control; Optical waveguides; biosensor; nanoparticle; planar interferometer; sensitivity;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems, 2007. NEMS '07. 2nd IEEE International Conference on
Conference_Location :
Bangkok
Print_ISBN :
1-4244-0610-2
DOI :
10.1109/NEMS.2007.352245
