Title :
Modeling studies of cellular response to ultrashort, high-intensity electric fields
Author :
Joshi, R.P. ; Hu, Q. ; Schoenbach, K.H. ; Lakdawala, V.K.
Author_Institution :
Dept. of Electr. & Comput. Eng., Old Dominion Univ., Norfolk, VA, USA
Abstract :
The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.
Keywords :
bioelectric phenomena; biological effects of fields; cancer; cellular effects of radiation; radiation therapy; Smoluchowski equations; biological cells; cancer cells; cell membranes; cell responses; cell substructures; cellular response; current continuity; distributed current model; dynamic conductivities; electroporation; pore formation; potential distribution; tonsillar B-cells; ultrashort high-intensity electric fields; Biological cells; Biological system modeling; Biomembranes; Cancer; Cells (biology); Circuit simulation; Conductivity; Equations; Nanobioscience; Solid modeling;
Conference_Titel :
Electrical Insulation and Dielectric Phenomena, 2003. Annual Report. Conference on
Print_ISBN :
0-7803-7910-1
DOI :
10.1109/CEIDP.2003.1254867
