• DocumentCode
    24262
  • Title

    Magnetic Fluid Hyperthermia Modeling Based on Phantom Measurements and Realistic Breast Model

  • Author

    Miaskowski, A. ; Sawicki, B.

  • Author_Institution
    Dept. of Appl. Math. & Comput. Sci., Univ. of Life Sci., Lublin, Poland
  • Volume
    60
  • Issue
    7
  • fYear
    2013
  • fDate
    Jul-13
  • Firstpage
    1806
  • Lastpage
    1813
  • Abstract
    Magnetic fluid hyperthermia (MFH) is a minimally invasive procedure that destroys cancer cells. It is based on a superparamagnetic heat phenomenon and consists in feeding a ferrofluid into a tumor, and then applying an external electromagnetic field, which leads to apoptosis. The strength of the magnetic field, optimal dose of the ferrofluid, the volume of the tumor and the safety standards have to be taken into consideration when MFH treatment is planned. In this study, we have presented the novel complementary investigation based both on the experiments and numerical methodology connected with female breast cancer. We have conducted experiments on simplified female breast phantoms with numerical analysis and then we transferred the results on an anatomically-like breast model.
  • Keywords
    bioelectric potentials; biomagnetism; cancer; cellular biophysics; hyperthermia; iron compounds; magnetic fluids; magnetoelectric effects; numerical analysis; phantoms; tumours; Fe3O4; MFH treatment plan; anatomically-like breast model; apoptosis; cancer cell destruction; complementary investigation; external electromagnetic field; female breast cancer; female breast phantoms; ferrofluid; magnetic field strength; magnetic fluid hyperthermia modeling; minimally invasive procedure; numerical analysis; numerical methodology; optimal dose; phantom measurements; realistic breast model; superparamagnetic heat phenomenon; tumor; Equations; Heating; Mathematical model; Numerical models; Phantoms; Temperature measurement; Tumors; Bioelectromagnetics; Pennes equation; magnetic fluid hyperthermia (MFH); Biomimetics; Body Temperature; Breast Neoplasms; Computer Simulation; Equipment Design; Equipment Failure Analysis; Female; Humans; Hyperthermia, Induced; Magnetic Field Therapy; Models, Biological;
  • fLanguage
    English
  • Journal_Title
    Biomedical Engineering, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0018-9294
  • Type

    jour

  • DOI
    10.1109/TBME.2013.2242071
  • Filename
    6418002