Title :
Theoretical and experimental study of electroporation of red blood cells using MEMS technology
Author :
Deng, Peigang ; Yin, Guangyao ; Zhang, Tong-Yi ; Chang, Donald C. ; Lee, Yi-Kuen
Author_Institution :
KAUST-HKUST Joint Micro/Nanofluidics Lab., Hong Kong Univ. of Sci. & Technol., Hong Kong, China
Abstract :
A theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC´s membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions.
Keywords :
bioelectric phenomena; biological effects of fields; biomembranes; blood; cellular biophysics; MEMS technology; RBC membrane; electroporation electric field strength; energy based model; microelectroporaion chip; red blood cell electroporation; strain energy; electroporation; micro electroporation chip; red blood cell; strain energy;
Conference_Titel :
Nano/Micro Engineered and Molecular Systems (NEMS), 2010 5th IEEE International Conference on
Conference_Location :
Xiamen
Print_ISBN :
978-1-4244-6543-9
DOI :
10.1109/NEMS.2010.5592472
