Title :
Light image patterned molecular delivery into live cells using gold particle coated substrate
Author :
Wu, Ting-Hsiang ; Kalim, Sheraz ; Callahan, Caitlin ; Teitell, Michael ; Chiou, Pei-Yu
Author_Institution :
Dept. of Electr. Eng., Univ. of California, Los Angeles, CA
Abstract :
Light-patterned molecular delivery into cells is demonstrated by pulsed laser irradiation of gold particles immobilized on the substrate below a cell monolayer. Molecular delivery is verified by observing the uptake of membrane-impermeable fluorescent dye.
Keywords :
biological effects of laser radiation; biological techniques; cellular effects of radiation; cellular transport; dyes; fluorescence; genetics; gold; laser beam applications; molecular biophysics; monolayers; Au; cell monolayer; gold particle coated substrate; gold particles immobilization; light image patterned molecular delivery; live cells; membrane-impermeable fluorescent dye uptake; optoporation; pulsed laser irradiation; Biomembranes; Cells (biology); Explosives; Fluorescence; Gold; Large-scale systems; Laser beams; Optical control; Optical pulses; Ultrafast optics;
Conference_Titel :
IEEE/LEOS Summer Topical Meetings, 2008 Digest of the
Conference_Location :
Acapulco
Print_ISBN :
978-1-4244-1925-8
Electronic_ISBN :
1099-4742
DOI :
10.1109/LEOSST.2008.4590556
