Splenic densities measurements and its relationship with the extent of pathologic changes

In this study, we measured the density of spleen by an integrated volume-density meter and correlated with their pathology changes. The densities of spleen from 134 autopsy cases were measured with different extent of pathologic changes by the meter. All samples were divided into 2 groups: intact and pathologic groups. The extent of pathologic changes was classified into 3 stages: fibrosis, slight edema, severe edema according to the histological features. Results show that there were significant differences between each subgroup and intact group and the density was closely correlated with pathologic changes. Therefore, the external parameter of density might offer some clues to its pathologic changes, such as edema and fibrosis.