Title :
DNA electrical detection based on inductor resonance frequency in standard CMOS technology
Author :
Laurent, G. ; Hagelsieb, L.M. ; Lederer, D. ; Lobert, P.E. ; Flandre, D. ; Remacle, J. ; Raskin, J.P.
Author_Institution :
Lab. de Microelectronique, Univ. Catholique de Louvain, Louvain-la-Neuve, Belgium
Abstract :
Several electrical methods have been studied for the detection of DNA hybridization on silicon chips, using capacitance or resistance changes of micro-arrays of electrode fingers. In this work, we studied the possibility of detecting DNA by the measurement of the resonance frequency shift of an inductor designed on Si substrate. Self-resonance frequency shift as large as 10 GHz before and after DNA hybridization has been measured for inductors made from standard CMOS process with a protective oxide coating and a DNA amplification based on silver enhancement.
Keywords :
CMOS integrated circuits; DNA; circuit resonance; electric sensing devices; inductors; DNA amplification; DNA electrical detection; DNA hybridization; electrical methods; electrode fingers microarrays; inductor resonance frequency; protective oxide coating; resonance frequency shift measurement; self-resonance frequency shift; silicon chips; silver enhancement; standard CMOS technology; CMOS technology; Capacitance; DNA; Electric resistance; Electrical resistance measurement; Frequency measurement; Inductors; Resonance; Resonant frequency; Silicon;
Conference_Titel :
Solid-State Circuits Conference, 2003. ESSCIRC '03. Proceedings of the 29th European
Conference_Location :
Estoril, Portugal
Print_ISBN :
0-7803-7995-0
DOI :
10.1109/ESSCIRC.2003.1257141
