Multiscale 3D model of cardiac contraction based on a fiber array

Author

Amar, A. ; Witman, S. ; Barnea, O.

Author_Institution

Dept. of Biomed. Eng., Tel Aviv Univ., Ramat Aviv, Israel

fYear

2012

fDate

14-17 Nov. 2012

Firstpage

1

Lastpage

5

Abstract

The heart has been modeled as an anatomically arranged and oriented array of contracting fibers. The model was developed to study the interplay between cellular mechanisms and global myocardial function. Our modeling approach combines cellular electrophysiology, force development, and anatomical ventricle model into a multiscale model of cardiac contraction. The model represents myocardial deformation and fluid dynamics. Results show that the multiscale ventricular model is capable of simulating mechanical contraction, pressure generation and load interactions.

Keywords

bioelectric phenomena; biomechanics; cardiology; cellular biophysics; muscle; physiological models; anatomical ventricle model; anatomically arranged contracting fiber array; anatomically oriented contracting fiber array; cardiac contraction multiscale model; cellular electrophysiology; cellular mechanisms; fiber array based cardiac contraction multiscale 3D model; fluid dynamics; force development; global myocardial function; load interactions; mechanical contraction; myocardial deformation; pressure generation; Biological system modeling; Calcium; Force; Heart; Mathematical model; Myocardium; Solid modeling; Mathematical model; cardiac contraction; cardiac electrophysiology;

fLanguage

English

Publisher

ieee

Conference_Titel

Electrical & Electronics Engineers in Israel (IEEEI), 2012 IEEE 27th Convention of

Conference_Location

Eilat

Print_ISBN

978-1-4673-4682-5

Type

conf

DOI

10.1109/EEEI.2012.6377090

Filename

6377090