Title :
Molecular Modeling Studies of AmpR Mediated AmpC ß-Lactamase Repression
Author :
Hecht, David A. ; Wang, Charles C N ; Hu, Rouh-Mei ; Tsai, Jeffrey J P
Author_Institution :
Dept. of Bioinf., Asia Univ., Taichung, Taiwan
Abstract :
Molecular modeling and in silico docking experiments were performed in order to study the mechanism of action of AmpC beta-Lactamase repression via AmpR binding of UDP-MurNAc-L-Ala-D-gamma-Glu-Meso-2,6-Diaminopimelete-D-Ala-D-Ala.
Keywords :
biochemistry; enzymes; molecular biophysics; AmpR binding; AmpR mediated AmpC β-lactamase repression; UDP-MurNAc-L-Ala-D-γGlu-meso-2,6-diaminopimelete-D-Ala-D-Ala; in-silico docking experiment; molecular modeling; Antibiotics; Compounds; Crystals; Gold; Immune system; Libraries; Proteins; ß-Lactamase; AmpC; AmpR; MRSA; antibiotic resistance; docking;
Conference_Titel :
Bioinformatics and Bioengineering (BIBE), 2011 IEEE 11th International Conference on
Conference_Location :
Taichung
Print_ISBN :
978-1-61284-975-1
DOI :
10.1109/BIBE.2011.37
