Title :
A cycle-averaged model of hypoplastic left heart syndrome (HLHS)
Author :
Jalali, Ali ; Nataraj, C.
Author_Institution :
Department of Mechanical Engineering at Villanova University, Villanova, PA 19085 USA
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
This paper is concerned with computational modeling of a severe congenital defect called Hypoplastic left heart syndrome (HLHS) that is the most common cardiac malformation with the highest likelihood of deaths in newborns. A lumped parameter model of the HLHS circulation has been developed to study the hemodynamic variables in the various sections of the cardio-pulmonary circulation system. We applied a short-term, cycle-averaging operation to the differential equations of the HLHS model to obtain the cycle-averaged model. Study has been carried out to analyze the variation of blood flow rate in different parts due to parameter changes. Results show that the developed model, could bring a good insight into understanding of the HLHS disease.
Keywords :
Arteries; Heart; Hemodynamics; Immune system; Mathematical model; Pediatrics; Valves; Blood Flow Velocity; Blood Pressure; Computer Simulation; Coronary Circulation; Humans; Hypoplastic Left Heart Syndrome; Models, Cardiovascular; Pulmonary Circulation;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6090030