Title :
Dispersion of refractoriness and unidirectional block in a model of ischemic myocardium
Author :
Maglaveras, N. ; Van Capelle, FJL ; Allessie, M. ; Sahakian, A.V. ; Pappas, C. ; Strintzis, M.
Author_Institution :
Aristotelian Univ. of Thessaloniki, Greece
Abstract :
Ischemia effects on propagation characteristics are studied in a one-dimensional model of myocardium using the Luo-Rudy model. In particular the effects of changes in electrophysiologic parameters on propagation block, action potential duration and the effects of premature impulses in propagation characteristics around the border zone between normal and ischemic tissue are studied. It is shown that the direction of propagation coupled with changes in coupling resistance and resting membrane potential plays a dramatic role in altering propagation characteristics and action potential duration spatial distribution
Keywords :
bioelectric potentials; cardiology; muscle; physiological models; Luo-Rudy model; action potential duration spatial distribution; coupling resistance; electrophysiologic parameters; ischemic myocardium model; premature impulses effects; propagation characteristics; propagation direction; refractoriness dispersion; resting membrane potential; unidirectional block; Biomembranes; Blood flow; Cells (biology); Conductivity; Difference equations; Extracellular; Finite difference methods; Injuries; Ischemic pain; Myocardium;
Conference_Titel :
Computers in Cardiology 1993, Proceedings.
Conference_Location :
London
Print_ISBN :
0-8186-5470-8
DOI :
10.1109/CIC.1993.378315
