Title :
Artificial baroreflex system restores volume tolerance in the absence of native baroreflex
Author :
Hosokawa, Kazuya ; Funakoshi, Kouta ; Tanaka, Atsushi ; Sakamoto, Takafumi ; Onitsuka, Ken ; Sakamoto, Kazuo ; Tobushi, Tomoyuki ; Fujino, Takeo ; Saku, Keita ; Murayama, Yoshinori ; Ide, Tomomi ; Sunagawa, Kenji
Author_Institution :
Kyushu University Graduate School of Medical Sciences, Department of Cardiovascular Medicine. 8128582 Higashi-ku, Maidashi 3-1-1, Fukuoka, Japan
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
The arterial baroreflex stabilizes arterial pressure by modulating the mechanical properties of cardiovascular system. We previously demonstrated that the baroreflex impairment makes the circulatory system extremely sensitive to volume overload and predisposes to pulmonary edema irrespective of left ventricular systolic function. To overcome the volume intolerance, we developed an artificial baroreflex system by directly stimulating the carotid sinus nerves in response to changes in arterial pressure. The artificial baroreflex system precisely reproduced the native arterial pressure response and restored physiological volume buffering function. We conclude that the artificial baroreflex system would be an attractive tool in preventing pulmonary edema in patients with impaired baroreflex function.
Keywords :
Baroreflex; Blood pressure; Electrodes; Heart; Physiology; Regulators; Animals; Baroreflex; Biomimetics; Blood Pressure; Blood Volume; Computer Simulation; Heart Rate; Models, Cardiovascular; Rats; Rats, Sprague-Dawley;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6090157