Title :
Parameter exploration of staircase-shape extracellular stimulation for targeted stimulation of myelinated axon
Author :
Ueno, Ayako ; Karashima, Akihiro ; Nakao, Mitsuyuki ; Katayama, Norihiro
Author_Institution :
Biomodeling Laboratory, Department of Applied Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, Japan
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
Spatio-temporal dynamics of a mathematical model of myelinated axon in response to staircase-shape extracellular electrical stimulation, which was developed for selective nerve stimulation, is investigated by the computer simulation. It is shown that the response is classified into four types: subthreshold response, cathodic excitation, anodal block and anodal break excitation. Based on the simulation results, simple diagrams representing the response characteristics of the axon are constructed as functions of stimulation parameters and distance between the axon and electrode. The diagram would be useful for determining simulation parameters for dynamic targeted stimulation of myelinated axon.
Keywords :
Arrays; Biomembranes; Electric potential; Electrodes; Extracellular; Mathematical model; Nerve fibers; Action Potentials; Animals; Computer Simulation; Electric Stimulation; Humans; Membrane Potentials; Models, Neurological; Nerve Fibers, Myelinated; Neural Conduction;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6090204
