DocumentCode :
2469198
Title :
Biophysical neural spiking and bursting dynamics in reconfigurable analog VLSI
Author :
Yu, Theodore ; Sejnowski, Terrence J. ; Cauwenberghs, Gert
Author_Institution :
Dept. of Electr. & Comput. Eng., UC San Diego, La Jolla, CA, USA
fYear :
2010
fDate :
3-5 Nov. 2010
Firstpage :
186
Lastpage :
189
Abstract :
We study a range of neural dynamics under variations in biophysical parameters implementing extended Morris-Lecar and Hodgkin-Huxley models in three gating variables. The dynamics are emulated in NeuroDyn, an analog VLSI programmable neural emulation platform with generalized channel kinetics and biophysical membrane dynamics. We present simulation and measurement results and observe consistent agreement over a wide regime of tonic spiking and intrinsic bursting dynamics through the variation of a single conductance parameter governing calcium recovery.
Keywords :
VLSI; bioelectric phenomena; biomembrane transport; medical computing; neurophysiology; Hodgkin-Huxley model; NeuroDyn; analog VLSI programmable neural emulation platform; biophysical membrane dynamics; biophysical neural spiking; calcium recovery; conductance parameter; extended Morris-Lecar model; gating variables; generalized channel kinetics; intrinsic bursting dynamics; neural dynamics; reconfigurable analog; tonic spiking; Adaptation model; Biological system modeling; Biomembranes; Calcium; Data models; Kinetic theory; Neurons;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2010 IEEE
Conference_Location :
Paphos
Print_ISBN :
978-1-4244-7269-7
Electronic_ISBN :
978-1-4244-7268-0
Type :
conf
DOI :
10.1109/BIOCAS.2010.5709602
Filename :
5709602
Link To Document :
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