Title :
A conformable microelectrode array (cMEA) with integrated electronics for peripheral nerve interfacing
Author :
Guo, Liang ; Clements, Isaac P. ; Li, Dustin ; Bellamkonda, Ravi V. ; DeWeerth, Stephen P.
Author_Institution :
Wallace H. Coulter Dept. of Biomed. Eng., Emory Univ., Atlanta, GA, USA
Abstract :
A high-resolution PDMS-based conformable microelectrode array (cMEA) with integrated electronics is implemented. The cMEA is incorporated into individual layers of a nanofiber-based nerve regeneration scaffold to create a novel regenerative electrode scaffold (RES) capable of establishing a stable, high-resolution peripheral nerve interface. The device features a compact size with an enhanced signal-to-noise ratio (SNR), as required by implantation applications. Preliminary characterizations of the device are performed using in vitro experimentations, including impedance spectroscopy and neural culturing.
Keywords :
biomedical electrodes; biomedical electronics; biomedical measurement; microelectrodes; neurophysiology; prosthetics; tissue engineering; PDMS-based conformable microelectrode array; cMEA; high-resolution peripheral nerve interface; impedance spectroscopy; integrated electronics; nanofiber-based nerve regeneration scaffold; neural culturing; peripheral nerve interfacing; regenerative electrode scaffold; signal-to-noise ratio; Arrays; Fabrication; Impedance; Microelectrodes; Substrates; Wires;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2010 IEEE
Conference_Location :
Paphos
Print_ISBN :
978-1-4244-7269-7
Electronic_ISBN :
978-1-4244-7268-0
DOI :
10.1109/BIOCAS.2010.5709604
