Title :
2A-2 Investigations into the Potential Contribution of a Thermal Mechanism for Pulsed High Intensity Focused Ultrasound Mediated Delivery
Author :
O´Neill, Brian E. ; Li, King C P ; Frenkel, Victor ; Vo, Howard ; Angstadt, Mary ; Wood, Bradford J. ; Quinn, Timothy P.
Author_Institution :
Methodist Hosp., Houston
Abstract :
The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.
Keywords :
biomedical ultrasonics; drugs; hyperthermia; muscle; nanoparticles; nanotechnology; patient treatment; drug delivery; fluorescent nanoparticle; mouse muscle; nonultrasonic hyperthermia; pHIFU treatment; pulsed high intensity focused ultrasound; thermal mechanism; ultrasound mediated delivery; Acoustic pulses; Acoustic transducers; Drug delivery; Hyperthermia; Mice; Muscles; Radiology; Temperature; Ultrasonic imaging; Ultrasonic variables measurement;
Conference_Titel :
Ultrasonics Symposium, 2007. IEEE
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-1384-3
Electronic_ISBN :
1051-0117
DOI :
10.1109/ULTSYM.2007.16
