2A-2 Investigations into the Potential Contribution of a Thermal Mechanism for Pulsed High Intensity Focused Ultrasound Mediated Delivery

Author

O´Neill, Brian E. ; Li, King C P ; Frenkel, Victor ; Vo, Howard ; Angstadt, Mary ; Wood, Bradford J. ; Quinn, Timothy P.

Author_Institution

Methodist Hosp., Houston

fYear

2007

fDate

28-31 Oct. 2007

Firstpage

1

Lastpage

4

Abstract

The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The delivery of 200 nm fluorescent nanoparticles was measured as a surrogate marker for drug delivery by pHIFU and HT treatments. Only the pHIFU treatment showed a significant increase in particle delivery.

Keywords

biomedical ultrasonics; drugs; hyperthermia; muscle; nanoparticles; nanotechnology; patient treatment; drug delivery; fluorescent nanoparticle; mouse muscle; nonultrasonic hyperthermia; pHIFU treatment; pulsed high intensity focused ultrasound; thermal mechanism; ultrasound mediated delivery; Acoustic pulses; Acoustic transducers; Drug delivery; Hyperthermia; Mice; Muscles; Radiology; Temperature; Ultrasonic imaging; Ultrasonic variables measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium, 2007. IEEE

Conference_Location

New York, NY

ISSN

1051-0117

Print_ISBN

978-1-4244-1384-3

Electronic_ISBN

1051-0117

Type

conf

DOI

10.1109/ULTSYM.2007.16

Filename

4409589