DocumentCode :
2469775
Title :
Amperometric instrumentation system with on-chip electrode array for biosensor application
Author :
Li, Lin ; Qureshi, Waqar A. ; Liu, Xiaowen ; Mason, Andrew J.
Author_Institution :
Electr. & Comput. Eng., Michigan State Univ., East Lansing, MI, USA
fYear :
2010
fDate :
3-5 Nov. 2010
Firstpage :
294
Lastpage :
297
Abstract :
An integrated amperometric instrumentation system with on-chip electrodes for biosensor arrays is presented. The mixed-signal integrated circuit supports a variety of electrochemical measurement techniques including linear sweep, constant potential, cyclic and pulse voltammetry. Implemented in 0.5 μm CMOS, the 3×3 mm2 chip dissipates 22.5 mW for a 200 kHz clock. The highly programmable chip provides a wide range of user-controlled rate and amplitude parameters with a maximum scan range of 2 V and scan rate ranging between 1mV/sec to 400V/sec. The amperometric readout circuit provides ± 0.5 pA linear resolution and supports inputs up to 100μA. A 2×2 array gold electrode electrochemical cells was fabricated on the surface of the CMOS instrumentation chip. An all-parylene packaging scheme was developed for compatibility with liquid test environments as well as harsh piranha electrode cleaning processes. The chip was tested using cyclic voltammetry of 0.1M potassium ferrocyanide, and results were comparable to measurements using commercial instruments.
Keywords :
CMOS integrated circuits; amperometric sensors; biosensors; cleaning; electrodes; integrated circuit packaging; integrated circuit testing; lab-on-a-chip; mixed analogue-digital integrated circuits; readout electronics; sensor arrays; CMOS instrumentation chip; all-parylene packaging scheme; amperometric readout circuit; amplitude parameters; array gold electrode electrochemical cells; biosensor arrays; commercial instruments; current -0.5 pA; current 0.5 pA; cyclic voltammetry; electrochemical measurement techniques; frequency 200 kHz; harsh piranha electrode cleaning processes; integrated amperometric instrumentation system; liquid test environments; mixed-signal integrated circuit; on-chip electrode array; potassium ferrocyanide; power 22.5 mW; programmable chip; pulse voltammetry; size 0.5 mum; user-controlled rate; voltage 2 V; Arrays; Biosensors; CMOS integrated circuits; Electrodes; Instruments; Signal generators; System-on-a-chip;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2010 IEEE
Conference_Location :
Paphos
Print_ISBN :
978-1-4244-7269-7
Electronic_ISBN :
978-1-4244-7268-0
Type :
conf
DOI :
10.1109/BIOCAS.2010.5709629
Filename :
5709629
Link To Document :
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