Title :
NIRS study of cerebral oxygenation and hemodynamics in neonate at birth
Author :
Hou, Xinlin ; Ding, Haiyan ; Teng, Yichao ; Zhou, Congle ; Zhang, Dandan
Author_Institution :
Dept. of Pediatrics, First Hosp. of Beijing Univ., Beijing, China
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
To study the changes of cerebral oxygenation and hemodynamics in normal neonates at 2-5 min post-birth and understand the effects of pregnancy-induced hypertension (PIH) upon cerebral oxygenation and hemodynamics in newborn neonates. The near infrared spectroscopy (NIRS) was employed to measure the absolute quantity of brain tissue oxygen saturation (rSO2) in newborn neonates and the changes of concentrations of deoxyhemoglobin (Hb) and oxygenation hemoglobin (HbO2) with time relative to initial values to further obtain the changes of total hemoglobin (tHb) and cerebral perfusion (denoted by HbD). In normal neonates at 2-5 min post-birth, rSO2 increased while tHb remained relatively stable and HbD increased. In neonates born of PIH mothers at 3-5 min post-birth, the changes of tHb were markedly higher than those in the normal infants, p<;0.05; at 2-5 min post-birth, the changes were markedly lower than the normal term infants. We concluded that NIRS can detect the changes of cerebral oxygenation and blood flow in a non-invasive and effective way.
Keywords :
biochemistry; biomedical measurement; blood; brain; haemodynamics; haemorheology; infrared spectroscopy; medical disorders; paediatrics; spectrochemical analysis; NIRS; PIH; brain tissue oxygen saturation; cerebral perfusion; deoxyhemoglobin concentration changes; near infrared spectroscopy; neonatal cerebral hemodynamics; neonatal cerebral oxygenation; pregnancy induced hypertension effects; total hemoglobin; Blood; Brain; Hemodynamics; Optical variables measurement; Pediatrics; Spectroscopy; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Female; Humans; Infant, Newborn; Male; Oximetry; Oxygen; Reproducibility of Results; Rheology; Sensitivity and Specificity; Spectroscopy, Near-Infrared;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6090289