Dynamical model of P53-Mdm2-P14/19ARF network to radiation in population of cells

Author

Liu, Hui ; Han, Yingrong ; Chen, Yafei ; Zhang, Suhua ; Zhao, Tongjun ; Zhan, Yong

Author_Institution

Inst. of Biophys., Hebei Univ. of Technol., Tianjin, China

fYear

2009

fDate

16-19 Oct. 2009

Firstpage

1

Lastpage

3

Abstract

From the recent experiments of gamma radiation and models given before, we study the dynamical model of p53 and Mdm2 regulated by p14/19ARF in population of cells. In order to study how they infect the mechanism of the negative feedback loop, we give numerical results to study the oscillatory features of p53, Mdm2 and p14/19ARF in population of cells. The dynamical model and results will help us understand the oscillatory features of p53, Mdm2 and p14/19ARF to radiation in population of cells.

Keywords

biocybernetics; biological effects of ionising radiation; cellular biophysics; feedback; oscillations; Mdm2 oscillatory features; P14-19ARF regulated Mdm2; P14-19ARF regulated P53; cell populations; negative feedback loop; network dynamical model; p14-19ARF oscillatory features; p53 oscillatory features; Cancer; DNA; Fellows; Gene expression; Genetic mutations; Negative feedback; Negative feedback loops; Neoplasms; Proteins; Stochastic processes; Dynamical Model; Mdm2; P14/19ARF; p53;

fLanguage

English

Publisher

ieee

Conference_Titel

Bio-Inspired Computing, 2009. BIC-TA '09. Fourth International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-3866-2

Electronic_ISBN

978-1-4244-3867-9

Type

conf

DOI

10.1109/BICTA.2009.5338108

Filename

5338108