Title :
AFM investigation of molecular level events at biomaterial-biological interface
Author :
Agnihotri, Aashiish ; Siedlecki, Christopher A.
Author_Institution :
Dept. of Bioeng., Pennsylvania State Univ., Hershey, PA, USA
Abstract :
Interaction of water and proteins with biomaterials constitutes the first events occurring at the biomaterial/biological interface, and these events are believed to guide further responses. In this study we report two aspects of these initial events as studied by atomic force microscopy (AFM). First the time dependent conformational changes in fibrinogen adsorbed on a model hydrophobic biomaterial (graphite) and second, the morphological changes in poly(urethane urea) associated with hydration
Keywords :
adsorption; atomic force microscopy; biomedical materials; blood; interface phenomena; molecular biophysics; molecular configurations; proteins; solvation; adsorbed fibrinogen; atomic force microscopy; biomaterial-biological interface; blood contacting biomaterials; blood-material interactions; graphite; hydration; microphase reorientation; model hydrophobic biomaterial; molecular height; molecular level events; morphological changes; phase images; plasma proteins; poly(urethane urea); structure-function relationships; time dependent changes; time dependent conformational changes; uniform distribution; Atomic force microscopy; Biological system modeling; Biomedical engineering; Blood; Plasmas; Polymers; Probes; Proteins; Surface morphology; Surgery;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999497
