Nerve degeneration in Huntington´s disease

Author

Sridhar, Brindha ; Micheli-Tzanakou, Evangelia

Author_Institution

Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA

fYear

2002

fDate

2002

Firstpage

203

Lastpage

204

Abstract

Huntington´s disease is a progressive, genetic, neurodegenerative disorder that causes emotional, behavioral and motor abnormalities. The disease progresses to death and the effects of the disease can only be controlled by medication for a short time. This paper primarily focuses on the mechanical aspect of the disease i.e. disease progression due to nerve degeneration. The purpose of this project was to simulate the disease and its progression. Simple but meaningful neural circuits were designed and tested with interesting and satisfying results

Keywords

diseases; genetics; neural nets; neurophysiology; physiological models; Huntington´s disease; cell death; disease progression; dopamine inhibition; feedback inhibition; fourth chromosome mutation; mitochondrial dysfunction; nerve degeneration; neural circuits; pathophysiology; seven neuron network; six neuron network; spiny neurons; striatum; thalamus; three neuron network; Biological cells; Circuit simulation; Circuit testing; Computational modeling; Degenerative diseases; Genetics; High definition video; Neurofeedback; Neurons; Proteins;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast

Conference_Location

Philadelphia, PA

Print_ISBN

0-7803-7419-3

Type

conf

DOI

10.1109/NEBC.2002.999536

Filename

999536