DocumentCode
2472039
Title
Alginate strings and their applications in spinal injury
Author
Kanakasabai, Saravanan ; Wheatley, M.A.
Author_Institution
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
fYear
2002
fDate
2002
Firstpage
223
Lastpage
224
Abstract
We have optimized a method for producing strings of alginate bioconjugated with a laminin pentapeptide that aids in cell adhesion. These strings are 400-500 μm in thickness. In vitro studies have shown that rat (NB2a) and human (SHSY5Y) neuroblastoma cell lines adhere to and differentiate on these modified alginate strings. These strings are strong enough to be surgically transplanted onto the spinal cord, and may ultimately help in bridging the gap at the injury site
Keywords
adhesion; biochemistry; cellular biophysics; surgery; alginate strings; carbodiimide chemistry; cell adhesion; cell anchorage; disrupted axons; in vitro studies; laminin pentapeptide bioconjugated; modified strings; neuroblastoma cell lines; neuronal attachment; neuronal differentiation; spinal injury applications; tissue engineering constructs; Adhesives; Antibiotics; Biological materials; Biomedical engineering; Bovine; Collision mitigation; Humans; Injuries; Needles; Nerve fibers;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location
Philadelphia, PA
Print_ISBN
0-7803-7419-3
Type
conf
DOI
10.1109/NEBC.2002.999546
Filename
999546
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