DocumentCode :
2473756
Title :
10A-3 Intravascular Photoacoustic Imaging with Gold Nanoparticles
Author :
Wang, Bo ; Yantsen, Evgeniya ; Larson, Timothy ; Sethuraman, Shriram ; Sokolov, Konstantin ; Emelianov, Stanislav
Author_Institution :
Univ. of Texas at Austin, Austin
fYear :
2007
fDate :
28-31 Oct. 2007
Firstpage :
848
Lastpage :
851
Abstract :
Intravascular photoacoustic (IVPA) imaging can image atherosclerotic plaques inside the artery by utilizing the differences in optical absorption between various tissue types. Combined intravascular ultrasound (IVUS) and IVPA imaging has the potential to visualize both the structure and composition of plaques. However, the molecular or cellular specific components of the plaques can be further enhanced by introducing plasmonic nanoparticles as molecularly targeted contrast agents. To demonstrate that IVPA imaging with optical contrast agents is possible, we performed IVUS and IVPA imaging of a vessel phantom containing murine macrophages with gold nanoparticles inside the cells. Several controls including gold nanoparticles suspended in gelatin and macrophages without nanoparticles were also imaged The results of our study suggest that IVPA is capable of imaging using gold nanoparticles as contrast agents. In addition, spectroscopic IVPA imaging can be used to distinguish aggregated nanoparticles from other tissue components and non- aggregated nanoparticles thus further enhancing the contrast of targeted components in the artery.
Keywords :
bio-optics; biomedical optical imaging; biomedical ultrasonics; blood vessels; cardiovascular system; cellular biophysics; diseases; gold; medical image processing; nanoparticles; nanotechnology; phantoms; photoacoustic effect; aggregated nanoparticles; atherosclerotic plaques; cellular specific components; combined IVUS - IVPA imaging; coronary artery; gelatin; gold nanoparticles; image contrast enhancement; intravascular photoacoustic imaging; intravascular ultrasound imaging; macrophages; molecular specific components; molecularly targeted contrast agents; murine macrophages; optical absorption; optical contrast agents; plasmonic nanoparticles; spectroscopic IVPA imaging; tissue-mimicking phantoms; vessel phantom; Absorption; Arteries; Gold; Imaging phantoms; Nanoparticles; Optical imaging; Plasmons; Spectroscopy; Ultrasonic imaging; Visualization;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium, 2007. IEEE
Conference_Location :
New York, NY
ISSN :
1051-0117
Print_ISBN :
978-1-4244-1384-3
Electronic_ISBN :
1051-0117
Type :
conf
DOI :
10.1109/ULTSYM.2007.217
Filename :
4409790
Link To Document :
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