Cerebral near-infrared spectroscopy analysis in preterm infants with intraventricular hemorrhage

Author

Zhang, Ying ; Chan, Gregory S H ; Tracy, Mark B. ; Lee, Qim Y. ; Hinder, Murray ; Savkin, Andrey V. ; Lovell, Nigel H.

Author_Institution

Sch. of Electr. Eng. & Telecommun., Univ. of New South Wales, Sydney, NSW, Australia

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

1937

Lastpage

1940

Abstract

Near-infrared spectroscopy (NIRS) for cerebral circulation monitoring has gained popularity in the neonatal intensive care setting, with studies showing the possibility of identifying preterm infants with intraventricular hemorrhage (IVH) by transfer function analysis of arterial blood pressure (BP) and NIRS measures. In this study, we examined a number of NIRS-derived measures in a cohort of preterm infants with IVH (n = 5) and without IVH (n = 12) within 1-3 hours after birth. The IVH infants were found to have significantly higher tissue oxygenation index (TOI), lower fractional tissue oxygen extraction (FTOE) and lower coherence between arterial BP and deoxygenated hemoglobin (HHb) in the very low frequency range (VLF, 0.02-0.04 Hz). Further studies with larger sample size are warranted for a more complete understanding of the clinical utility of these NIRS measures for early identification of IVH infants.

Keywords

blood vessels; brain; electrocardiography; infrared spectra; molecular biophysics; proteins; transfer functions; arterial blood pressure; cerebral circulation monitoring; cerebral near-infrared spectroscopy analysis; deoxygenated hemoglobin; electrocardiogram; fractional tissue oxygen extraction; frequency 0.02 Hz to 0.04 Hz; intraventricular hemorrhage; neonatal intensive care setting; preterm infants; time 1 h to 3 h; transfer function analysis; Australia; Biomedical measurements; Coherence; Hemorrhaging; Pediatrics; Spectroscopy; Transfer functions; Cerebral Hemorrhage; Cerebral Ventricles; Female; Hemoglobins; Humans; Infant, Newborn; Infant, Premature; Male; Oxygen; Reproducibility of Results; Sensitivity and Specificity; Spectroscopy, Near-Infrared;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6090547

Filename

6090547