DocumentCode :
2476702
Title :
Chronic behavior evaluation of a micro-machined neural implant with optimized design based on an experimentally derived model
Author :
Andrei, Alexandru ; Welkenhuysen, Marleen ; Ameye, Lieveke ; Nuttin, Bart ; Eberle, Wolfgang
Author_Institution :
Bioelectron. Syst. Group, Imec, Heverlee, Belgium
fYear :
2011
fDate :
Aug. 30 2011-Sept. 3 2011
Firstpage :
2292
Lastpage :
2295
Abstract :
Understanding the mechanical interactions between implants and the surrounding tissue is known to have an important role for improving the bio-compatibility of such devices. Using a recently developed model, a particular micro-machined neural implant design aiming the reduction of insertion forces dependence on the insertion speed was optimized. Implantations with 10 and 100 μm/s insertion speeds showed excellent agreement with the predicted behavior. Lesion size, gliosis (GFAP), inflammation (ED1) and neuronal cells density (NeuN) was evaluated after 6 week of chronic implantation showing no insertion speed dependence.
Keywords :
bioMEMS; cellular biophysics; micromachining; neurophysiology; optimisation; prosthetics; biocompatibility; chronic behavior evaluation; experimentally derived model; gliosis; inflammation; insertion speed; lesion size; mechanical interactions; micromachined neural implant; neuronal cells density; optimized design; surrounding tissue; time 6 week; Force; Geometry; Implants; Probes; Shafts; Shape; Silicon; Animals; Brain Diseases; Equipment Failure Analysis; Longitudinal Studies; Male; Miniaturization; Prostheses and Implants; Prosthesis Design; Rats; Rats, Wistar;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2011.6090577
Filename :
6090577
Link To Document :
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