Title :
Dual-axes confocal microscopy for clinical skin imaging
Author :
Piyawattanametha, W. ; Ra, H. ; Mandella, M.J. ; Gonzalez, E. ; Kaspar, R. ; Kino, G.S. ; Contag, C.H. ; Solgaard, O.
Author_Institution :
Edward L. Ginzton Lab., Stanford Univ., Stanford, CA, USA
Abstract :
We demonstrate MEMS based near infrared fluorescence dual-axes confocal (DAC) imaging in a 10-mm-diameter microscope for three-dimensional (3-D) imaging of in vivo human skin. The probe is used to reveal mosaicing two-dimensional (2-D) en face sub-surface histology at depths of up to 250 mum. The probe has a maximum field of view (FOV) of 800times450 mum2 and a maximum acquisition rate of 10 frames/second. The transverse and axial resolutions are 5 mum and 7 mum, respectively.
Keywords :
biomedical optical imaging; micromechanical devices; optical microscopy; probes; skin; MEMS; clinical human skin imaging; depth 250 mum; dual-axes confocal microscopy; near-infrared fluorescence dual-axes confocal imaging; probe; size 10 mm; size 5 mum; size 7 mum; three-dimensional imaging; two-dimensional en face subsurface histology mosaicing; Fluorescence; Humans; In vivo; Infrared imaging; Micromechanical devices; Microscopy; Optical imaging; Probes; Skin; Two dimensional displays;
Conference_Titel :
Optical MEMS and Nanophotonics, 2009 IEEE/LEOS International Conference on
Conference_Location :
Clearwater, FL
Print_ISBN :
978-1-4244-2382-8
Electronic_ISBN :
978-1-4244-2382-8
DOI :
10.1109/OMEMS.2009.5338633
