Cr(VI) with curcumin and hydrogen peroxide causes DNA damage

Author

Zhang, Jun ; Shi, Xiaoting ; Yang, Hong ; Zhang, Zhong

Author_Institution

Sch. of Chem. & Chem. Eng., Inner Mongolia Univ., Hohhot, China

fYear

2011

fDate

24-26 June 2011

Firstpage

7472

Lastpage

7474

Abstract

DNA conformational change and breakage induced by Cr(VI) and curcumin in the present of H₂O₂ were characterized by the atomic force microscopy. Incubation of DNA with curcumin and Cr(VI) in the presence of H₂O₂ caused DNA double-strand breaks significantly. Cr(VI) and H₂O₂ also breaked mildly DNA double-strands. On the basis of these results, we think hydroxyl radicals and reactive oxygen species can play a principal role in this DNA damage system.

Keywords

DNA; atom-molecule reactions; atomic force microscopy; biochemistry; biological techniques; chromium; free radicals; hydrogen compounds; molecular biophysics; molecular configurations; molecule-molecule reactions; Cr; DNA breakage; DNA conformational change; DNA damage; DNA double strand breakage; H₂O₂; atomic force microscopy; chromium; curcumin; hydrogen peroxide; hydroxyl radical; incubation; reactive oxygen species; Atomic force microscopy; Atomic measurements; DNA; Force; Humans; Metals; Cr(VI) double-strand; DNA break; curcumin;

fLanguage

English

Publisher

ieee

Conference_Titel

Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on

Conference_Location

Nanjing

Print_ISBN

978-1-4244-9172-8

Type

conf

DOI

10.1109/RSETE.2011.5966098

Filename

5966098