Title :
Lipid lowering activity of (E)-3-[4-[2-(4-chlorophenoxy)-2-methylpropanoylox y]-3-methoxyphenyl] acrylic acid (AZ) in hyperlipidemic rats
Author :
Chen, Xiao-Bing ; Xu, Jun ; Zhao, Po ; Yang, Zun-Hua ; Peng, Hong
Author_Institution :
Lab. for Pharmacochemistry, JiangXi Univ. of Traditional Chinese Med., Nanchang, China
Abstract :
Hyperlipidemia is closely related to Cardiovascular Disease, and also an important risk factor to affect Atherosclerosis, Coronary Heart Disease (CHD) and other Cardiovascular Disease. And hyperlipidemia could severely affect the health of human. In order to find better biological activity of lowering blood-lipids, we introduced the target compound of AZ. The lead compound were designed and synthesized by chlorophenoxy isobutyric acid of chemical lowering blood-lipid drugs and ferulic acid which is traditional Chinese medicine active products. The structure of the target compound prepared were confirmed by IR,MS, 1H-NMR,and elemental analysis. The herbicidal results show that the target compound has good lowering hyperlipidemia activities.
Keywords :
cardiovascular system; diseases; drugs; organic compounds; (E)-3 [4[2-(4-chlorophenoxy )-2-methy lpropanoy loxy]-3-methoxyphenyl] acrylic acid; atherosclerosis; cardiovascular disease; chlorophenoxy isobutyric acid; coronary heart disease; drugs; ferulic acid; hyperlipidemia; hyperlipidemic rats; lipid lowering activity; risk factor; traditional Chinese medicine; Atherosclerosis; Biological system modeling; Blood; Compounds; Drugs; Lipidomics; Rats; Biological activities; Esterification; Hyperlipidemia; Synthesis;
Conference_Titel :
Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on
Conference_Location :
Nanjing
Print_ISBN :
978-1-4244-9172-8
DOI :
10.1109/RSETE.2011.5966150
