Title :
Handheld bio-impedance measurement system based on an instrument-on-chip
Author :
Rottigni, Angelo ; Carminati, Marco ; Ferrari, Giorgio ; Sampietro, Marco
Author_Institution :
Dipt. di Elettron. e Inf., Politec. di Milano, Milan, Italy
Abstract :
In this paper we present a compact system for impedance measurement in the kHz-MHz frequency range with attoFarad resolution. It has been designed to address micro- and nano-scale bio-sensing applications, such as impedimetric flow cytometry or molecular affinity bio-sensors. The core of the detection system is an integrated circuit that features a low noise current amplifier, a two-phase square waveform lock-in detector and two ΣΔ analog-to-digital converters. The CMOS chip is complemented by all the blocks needed to perform spectroscopy measurements, including versatile signal generation, digital processing and PC data transmission. The whole stand-alone system is USB powered and can reach sub-fF resolution in capacitive tracking on a sub-millisecond time scale.
Keywords :
CMOS integrated circuits; biosensors; electric impedance measurement; lab-on-a-chip; low noise amplifiers; microsensors; nanosensors; peripheral interfaces; sigma-delta modulation; ΣΔ analog-to-digital converters; CMOS chip; PC data transmission; USB; attoFarad resolution; detection system; digital processing; handheld bioimpedance measurement system; impedimetric flow cytometry; instrument-on-chip; integrated circuit; lab-on- a-chip; low noise current amplifier; microscale biosensing; molecular affinity biosensors; nanoscale biosensing; spectroscopy measurements; two-phase square waveform lock-in detector; versatile signal generation; CMOS integrated circuits; Capacitance; Frequency measurement; Impedance; Impedance measurement; Instruments; Noise; CMOS Lock-in; Impedance spectroscopy; Lab-ona-Chip;
Conference_Titel :
Ph.D. Research in Microelectronics and Electronics (PRIME), 2011 7th Conference on
Conference_Location :
Trento
Print_ISBN :
978-1-4244-9138-4
Electronic_ISBN :
978-1-4244-9136-0
DOI :
10.1109/PRIME.2011.5966214
