Electrochemical impedance spectroscopy study of the cells adhesion over microelectrodes array

Author

Ferrario, A. ; Scaramuzza, M. ; Pasqualotto, E. ; De Toni, A. ; Paccagnella, A. ; Maschietto, M. ; Vassanelli, S.

Author_Institution

Dept. of Inf. Eng., Univ. of Padova, Padova, Italy

fYear

2011

fDate

3-7 July 2011

Firstpage

57

Lastpage

60

Abstract

Electrochemical Impedance Spectroscopy (EIS) has been widely used in biological studies like tissue and cells characterization, both in vivo and in vitro. The objective of this study was to investigate cells adhesion over a microelectrodes array by monitoring the electrical impedance. A comprehensive electrical model of the cell-electrode interface has been used to fit experimental data. The electrode surface coverage has been evaluated both with the variation of impedance measurements and with the variation of parameters extracted from the electrical model. A cover factor β has been used in the model in order to quantify the presence of different number of cells over an electrode surface.

Keywords

adhesion; biological tissues; biomedical measurement; electric impedance measurement; electrochemical impedance spectroscopy; microelectrodes; EIS; biological study; cell-electrode interface; cells adhesion; comprehensive electrical model; cover factor β; electrical impedance monitoring; electrochemical impedance spectroscopy; electrode surface coverage; impedance measurement variation; microelectrodes array; Impedance; Impedance measurement; Mathematical model; Microelectrodes; Resistance; Surface impedance; MATLAB; cell adhesion; electrical model; impedance spectroscopy; microelectrode;

fLanguage

English

Publisher

ieee

Conference_Titel

Ph.D. Research in Microelectronics and Electronics (PRIME), 2011 7th Conference on

Conference_Location

Trento

Print_ISBN

978-1-4244-9138-4

Electronic_ISBN

978-1-4244-9136-0

Type

conf

DOI

10.1109/PRIME.2011.5966216

Filename

5966216