Design of a cantilever-based system for DNA detection

Author

Adami, Andrea ; Borghetti, Fausto ; Massari, Nicola ; Decarli, Massimiliano ; Collini, Cristian ; Lorenzelli, Leandro ; Stoppa, David

Author_Institution

Center for Mater. & Microsyst., FBK - Fondazione Bruno Kessler, Trento, Italy

fYear

2011

fDate

3-7 July 2011

Firstpage

61

Lastpage

64

Abstract

In this work we present the development of a system intended for DNA label free detection, based on piezoresistive microcantilever arrays and dedicated readout ASIC. Detector design and microfabrication technologies have been optimised for detection sensitivity, providing an efficient direct electrical measurement of DNA hybridisation. Readout ASIC has been implemented using a 0.35μm CMOS technology to provide a high resolution and low noise readout of the sensors, by also providing the compensation of large offset in the detector response.

Keywords

CMOS integrated circuits; DNA; application specific integrated circuits; bioMEMS; biomedical electronics; biosensors; cantilevers; electrochemical sensors; microfabrication; molecular biophysics; piezoresistive devices; readout electronics; CMOS technology; DNA hybridisation; cantilever based DNA detection system; dedicated readout ASIC; detection sensitivity; detector design; detector response; direct electrical measurement; high resolution low noise readout; label free DNA detection; microfabrication technologies; piezoresistive microcantilever arrays; Application specific integrated circuits; Calibration; DNA; Detectors; Gold; Resistors; ASIC design; DNA biosensors; MEMS cantilevers;

fLanguage

English

Publisher

ieee

Conference_Titel

Ph.D. Research in Microelectronics and Electronics (PRIME), 2011 7th Conference on

Conference_Location

Trento

Print_ISBN

978-1-4244-9138-4

Electronic_ISBN

978-1-4244-9136-0

Type

conf

DOI

10.1109/PRIME.2011.5966217

Filename

5966217