Title :
Synthesis of novel antofine and Cryptopleurine analogues
Author :
Song, Yanling ; Meng, Yanqiu
Author_Institution :
Dept. of Pharm. Eng., Shenyang Univ. of Chem. Technol., Shenyang, China
Abstract :
Antofine and Cryptopleurine, natural products belong to the phenanthroindolizidine and phenanthroquinolizidine group of alkaloids, have attracted much attention because of their extremely potent inhibition of cancer cell growth. In this paper, seven analogues with different substituents on phenanthrene ring were designed and synthesized, the chemical structures of these derivatives were characterized by MS and 1H-NMR.
Keywords :
biological NMR; cancer; mass spectra; molecular biophysics; molecular configurations; organic compounds; 1H-NMR technique; Antofine analogues; Cryptopleurine analogues; MS technique; alkaloids; cancer cell growth; chemical structure; phenanthrene ring; phenanthroindolizidine group; phenanthroquinolizidine group; Cryptography; Heating; Nitrogen; Silicon compounds; Solvents; Suspensions; Antofine; Cryptopleurine; analogues; design; synthesis;
Conference_Titel :
Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on
Conference_Location :
Nanjing
Print_ISBN :
978-1-4244-9172-8
DOI :
10.1109/RSETE.2011.5966287
